During much of the Spanish colonial period, Santo Domingo was an important Franciscan mission center and the ecclesiastical capital of New Mexico. A mission church erected here before 1607 by Fray Juan de Escalona, was considered one of the largest and finest in New Mexico.
The Mission at San Ildefonso became the center of Franciscan activity in the north when first built. The church was burned down in the Indian revolt of 1696 and then rebuilt later by the Spanish. The new church remained practically unaltered until 1905, when several substantial alterations were made and the church was nearly entirely rebuilt.
Zuni Pueblo, after the mission’s reestablishment yet again, the Zunis joined the general pueblo uprisings in 1680 and destroyed Mission La Purísima Concepción a final time. The Zuni and the Spanish then abandoned Hawikuh completely, never occupying it again.