Después del restablecimiento de las misiones en la región, los Zunis se unieron a las luchas armadas del pueblo en 1680 destruyendo a la Misión de la Purísima Concepción, Tanto los Zunis como los españoles abandonaron Hawikuh por completo, sin regresar nunca más. 

The Inglesia de San Isidro is the earlier of two churches at Gran Quivira. Built between 1630 and 1635 of limestone quarried on site, the church measured 109 feet long by 29 feet wide. Inglesia de San Isidro was very similar in design to the church at Abó. A campo santo, or walled cemetery, is attached to the structure just east of the church.

Zuni Pueblo, after the mission’s reestablishment yet again, the Zunis joined the general pueblo uprisings in 1680 and destroyed Mission La Purísima Concepción a final time. The Zuni and the Spanish then abandoned Hawikuh completely, never occupying it again.