La Misión fue iniciada por el padre Antonio de San Buenaventura y Olivares en 1716, este Hito Historico Nacional  y Estatal fue originalmente situado al oeste del manantial de San Pedro.  Sobrevivió tres cambios de sitio y durante el siglo XIX sufrió los diversos enfrentamientos de control político y militar que pasaban en Texas.  Este rudimentario fuerte hace de la misión un sitio simbólico y estratégico dentro de la historia de Texas.  

Started by Father Antonio de San Buenaventura y Olivares in 1716, this National and State Historic Landmark was originally located west of San Pedro Springs. It survived three moves. During the 19th century struggle for political and military control of Texas. These rudimentary fortifications made the old mission symbolically and strategically important for Texas history.

Ysleta Mission was constructed in 1744 in part to serve the Tigua Indian community which had fled New Mexico during the Pueblo Revolt. The site was also known by the Spaniards as Corpus Christi de la Isleta. In 1881 the Jesuits took over the church and renamed it Nuestra Señora del Monte Carmelo.The present church was constructed in 1851. Its distinctive silver-domed bell tower was added in 1897.