Santa Clara Pueblo was first visited in 1541 by part of Francisco Vásquez de Coronado's expeditionary force. A mission was established in 1628 as a visita  for San Juan Pueblo. In 1680 the inhabitants of Santa Clara took an active part in the Great Pueblo Revolt against the Spanish. The historic section of the pueblo complex consists of one- and two-story adobe houses surrounding two main plazas with two rectangular ceremonial kivas and a church, c. 1918.

Zuni Pueblo, after the mission’s reestablishment yet again, the Zunis joined the general pueblo uprisings in 1680 and destroyed Mission La Purísima Concepción a final time. The Zuni and the Spanish then abandoned Hawikuh completely, never occupying it again.

Founded by Father Kino, originally a Jesuit mission, taken over by Franciscans who rebuilt it around 1800. The mission was involved in mining, smelting, ranching, and farming activities. The national historic park has a replanted orchard and visitor center.

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Ysleta Mission was constructed in 1744 in part to serve the Tigua Indian community which had fled New Mexico during the Pueblo Revolt. The site was also known by the Spaniards as Corpus Christi de la Isleta. In 1881 the Jesuits took over the church and renamed it Nuestra Señora del Monte Carmelo.The present church was constructed in 1851. Its distinctive silver-domed bell tower was added in 1897.