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Oldest mission site yet discovered in Spanish Texas, the oldest European site yet discovered in East Texas and the oldest site yet discovered known to bear the name Tejas.

Isleta Pueblo was established prior to the 1598 Spanish occupation of New Mexico and was burned during the Spanish attempt to reconquer the area following the 1680 Great Pueblo Revolt.

Construction of this mission began in 1627 by Fray Juan Gutiérrez de la Chica. At its peak, the Quarai pueblo had approximately 1,000 rooms and housed between 600 and 700 residents of both native and Spanish decent. The pueblo buildings were arranged around a number of small plazas.