Built on a rocky hill for Keresan'speaking people from Acoma, Santo Domingo, and Cohití, this church was constructed with stone and adobe in 1701, following the social upheavals caused by the 1680 Pueblo Revolt.
Isleta Pueblo was established prior to the 1598 Spanish occupation of New Mexico and was burned during the Spanish attempt to reconquer the area following the 1680 Great Pueblo Revolt.
Spanish Jesuits founded San Cayetano de Calabazas in 1756 after reorganizing their settlements in the wake of the 1751 Pima Revolt.