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Nuestra Señora de la Concepción del Socorro was founded in 1682 by the Franciscan order to serve displaced American Indians (the Piro, Tano and Jemez) from New Mexico, who fled during the Pueblo Revolt.

During much of the Spanish colonial period, Santo Domingo was an important Franciscan mission center and the ecclesiastical capital of New Mexico. A mission church erected here before 1607 by Fray Juan de Escalona, was considered one of the largest and finest in New Mexico.

Positioned in the mountains north of Santa Fe on the high road to Taos, the pueblo of Pícuris remains small and quiet. Fray Francisco de Zamora was charged with the establishment of the permanent mission, which was built around 1620.

Isleta Pueblo was established prior to the 1598 Spanish occupation of New Mexico and was burned during the Spanish attempt to reconquer the area following the 1680 Great Pueblo Revolt.

The Mission Church of Nuestra Señora de la Asunción at Zia rests on a mesa looking eastward. Zía was the principal settlement of Cumanes province. Fray Alonso de Lugo was placed in charge of Zia in 1598 and the first church followed soon thereafter.